Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...

** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to improve event-free and overall survival in cisplatin-eligible patients with muscle-invasive bladder cancer.**
- Pfizer's PADCEV and Merck's Keytruda combination shows significant survival benefits in muscle-invasive bladder cancer patients.
- The treatment avoids the use of platinum-based chemotherapy, marking a notable advancement in oncology.
- Market participants are observing potential impacts on pharmaceutical stocks and related healthcare sectors.
Pfizer Inc. and Merck & Co. have announced a significant breakthrough in the treatment of muscle-invasive bladder cancer. Their combined therapy, PADCEV and Keytruda, has demonstrated improved survival rates for patients eligible for cisplatin, without the need for traditional platinum-based chemotherapy. This development is noteworthy as it represents a shift in treatment paradigms, potentially impacting the pharmaceutical landscape.
The announcement has sparked discussions among market participants regarding the implications for Pfizer (PFE) and Merck (MRK) stocks. The positive clinical outcomes could enhance the competitive positioning of both companies in the oncology sector, potentially driving investor interest. Analysts note that the avoidance of platinum-based chemotherapy could appeal to a broader patient base, possibly increasing the market share for this treatment combination.
The broader healthcare sector, particularly companies involved in oncology, may also see ripple effects from this development. Investors are likely to monitor how this advancement influences the competitive dynamics within the sector. The news could lead to increased scrutiny of other pharmaceutical companies' pipelines, especially those focusing on cancer treatments.
In the context of the current market environment, where innovation in healthcare is a key driver of stock performance, this announcement could lead to heightened activity in related ETFs such as the Health Care Select Sector SPDR Fund (XLV) and the iShares U.S. Healthcare ETF (IYH). These funds provide exposure to a broad range of healthcare companies, including those at the forefront of cancer treatment innovations.
Traders are also considering the potential impact on the broader market sentiment towards pharmaceutical stocks. The success of this treatment could lead to increased investor confidence in the sector, potentially influencing trading volumes and price movements.
Trader Insight:
- Some traders may consider monitoring Pfizer (PFE) and Merck (MRK) for potential stock price movements following the announcement.
- Market participants are watching healthcare ETFs like XLV and IYH for signs of increased interest in the sector.
- Analysts note that traders are assessing the impact of this development on the competitive landscape in oncology, which could influence positioning in related stocks.
Disclaimer: This is not trading advice. For informational purposes only.
Merck (MRK) initiates Phase 3 KANDLELIT-007 Trial Evaluating Calderasib (MK-1...
Merck (MRK) initiates Phase 3 KANDLELIT-007 Trial Evaluating Calderasib (MK-1084), an Investigational Oral KRAS...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...
Merck & Co Inc
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...

BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley
** BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley** Core Scientific (CORZ) receives an...

US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
** US FDA moving to fast-track reviews of two Merck (MRK) drugs under commissioner national priority voucher pilot...
Pfizer Inc
Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
** Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance; sees FY25 revenue guidance at USD 62bln...
US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
** US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP** Ford's strategic shift away from electric vehicles (EVs) is...
Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030
** Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030** Pfizer anticipates growth in...

US President Trump set to interview Fed Governor Waller for the Chair role on...
** US President Trump set to interview Fed Governor Waller for the Chair role on Wednesday, WSJ reports** Betting...

Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Pharmaceuticals
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of ...
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of Pfizer (PFE) drugs for five years...
Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...

US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...

GSK (GSK LN)
GSK (GSK LN), Sanofi (SAN FP) and Merck (MRK) reportedly among seven companies set to announce price cuts, via...

PRE-MARKET AUSTRALIAN STOCKS NEWS
PRE-MARKET AUSTRALIAN STOCKS NEWS ANZ Group faces significant financial penalties, impacting the banking sector....
European Movers: Telecom Italia (TIT IM) +1.4%
European Movers: Telecom Italia (TIT IM) +1.4%, Harbour Energy (HBR LN) +1.3%, Roche (ROG SW) -0.5%, GSK (GSK LN)...
ECB's Kazimir says that the ECB remains flexible and will be ready to step in...
ECB's Kazimir says that the ECB remains flexible and will be ready to step in if needed. Analysts express concern...
US Consumer Confidence* (Dec) 89.1 vs. Exp. 91.0 (Prev. 88.7, Rev. 92.9)
US Consumer Confidence (Dec) 89.1 vs. Exp. 91.0 (Prev. 88.7, Rev. 92.9) * Traders are closely monitoring the...
European Movers: BP (BP/ LN) +1.4%, Elis (ELIS FP) -0.2%, Sanofi (SAN FP) -0.3%
European Movers: BP (BP/ LN) +1.4%, Elis (ELIS FP) -0.2%, Sanofi (SAN FP) -0.3% BP's sale of a majority stake in...
European spokesperson says there has been progress on the Mercosur deal durin...
European spokesperson says there has been progress on the Mercosur deal during the last two weeks; on track to...
European Movers: Sika (SIKA SW) +0.6%
** European Movers: Sika (SIKA SW) +0.6%, Unilever (?? LN) +0.5%, Orange (ORA FP) -0.5%, Smith & Nephew (SN/ LN)...
Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
** Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance; sees FY25 revenue guidance at USD 62bln...

US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
** US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP** Ford's strategic shift away from electric vehicles (EVs) is...

Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030
** Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030** Pfizer anticipates growth in...

BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
** BMW (BMY GY) says planned conversion of all preferred shares into ordinary shares; further details will be...
Pharmaceuticals (Group)
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of ...
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of Pfizer (PFE) drugs for five years...
Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...

US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...

GSK (GSK LN)
GSK (GSK LN), Sanofi (SAN FP) and Merck (MRK) reportedly among seven companies set to announce price cuts, via...

PRE-MARKET AUSTRALIAN STOCKS NEWS
PRE-MARKET AUSTRALIAN STOCKS NEWS ANZ Group faces significant financial penalties, impacting the banking sector....
European Movers: Telecom Italia (TIT IM) +1.4%
European Movers: Telecom Italia (TIT IM) +1.4%, Harbour Energy (HBR LN) +1.3%, Roche (ROG SW) -0.5%, GSK (GSK LN)...
ECB's Kazimir says that the ECB remains flexible and will be ready to step in...
ECB's Kazimir says that the ECB remains flexible and will be ready to step in if needed. Analysts express concern...
US Consumer Confidence* (Dec) 89.1 vs. Exp. 91.0 (Prev. 88.7, Rev. 92.9)
US Consumer Confidence (Dec) 89.1 vs. Exp. 91.0 (Prev. 88.7, Rev. 92.9) * Traders are closely monitoring the...
European Movers: BP (BP/ LN) +1.4%, Elis (ELIS FP) -0.2%, Sanofi (SAN FP) -0.3%
European Movers: BP (BP/ LN) +1.4%, Elis (ELIS FP) -0.2%, Sanofi (SAN FP) -0.3% BP's sale of a majority stake in...
European spokesperson says there has been progress on the Mercosur deal durin...
European spokesperson says there has been progress on the Mercosur deal during the last two weeks; on track to...
European Movers: Sika (SIKA SW) +0.6%
** European Movers: Sika (SIKA SW) +0.6%, Unilever (?? LN) +0.5%, Orange (ORA FP) -0.5%, Smith & Nephew (SN/ LN)...
Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
** Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance; sees FY25 revenue guidance at USD 62bln...

US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
** US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP** Ford's strategic shift away from electric vehicles (EVs) is...

Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030
** Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030** Pfizer anticipates growth in...

BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
** BMW (BMY GY) says planned conversion of all preferred shares into ordinary shares; further details will be...
Pharmaceuticals, Biotechnology & Life Sciences
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of ...
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of Pfizer (PFE) drugs for five years...
Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...

US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...

GSK (GSK LN)
GSK (GSK LN), Sanofi (SAN FP) and Merck (MRK) reportedly among seven companies set to announce price cuts, via...

PRE-MARKET AUSTRALIAN STOCKS NEWS
PRE-MARKET AUSTRALIAN STOCKS NEWS ANZ Group faces significant financial penalties, impacting the banking sector....
European Movers: Telecom Italia (TIT IM) +1.4%
European Movers: Telecom Italia (TIT IM) +1.4%, Harbour Energy (HBR LN) +1.3%, Roche (ROG SW) -0.5%, GSK (GSK LN)...
ECB's Kazimir says that the ECB remains flexible and will be ready to step in...
ECB's Kazimir says that the ECB remains flexible and will be ready to step in if needed. Analysts express concern...
Gilead (GILD) assembly bio to receive USD 35mln for its HSV option
Gilead (GILD) assembly bio to receive USD 35mln for its HSV option Traders are closely monitoring the energy...
US Consumer Confidence* (Dec) 89.1 vs. Exp. 91.0 (Prev. 88.7, Rev. 92.9)
US Consumer Confidence (Dec) 89.1 vs. Exp. 91.0 (Prev. 88.7, Rev. 92.9) * Traders are closely monitoring the...
European Movers: BP (BP/ LN) +1.4%, Elis (ELIS FP) -0.2%, Sanofi (SAN FP) -0.3%
European Movers: BP (BP/ LN) +1.4%, Elis (ELIS FP) -0.2%, Sanofi (SAN FP) -0.3% BP's sale of a majority stake in...
CATL's (300750 CH) Yichun lithium mine is expected to recommence production a...
CATL's (300750 CH) Yichun lithium mine is expected to recommence production around Chinese New Year, via Chinese...
European spokesperson says there has been progress on the Mercosur deal durin...
European spokesperson says there has been progress on the Mercosur deal during the last two weeks; on track to...

European Movers: Sika (SIKA SW) +0.6%
** European Movers: Sika (SIKA SW) +0.6%, Unilever (?? LN) +0.5%, Orange (ORA FP) -0.5%, Smith & Nephew (SN/ LN)...

Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
** Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance; sees FY25 revenue guidance at USD 62bln...

US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
** US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP** Ford's strategic shift away from electric vehicles (EVs) is...
MRK.US
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...

BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley
** BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley** Core Scientific (CORZ) receives an...

US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
** US FDA moving to fast-track reviews of two Merck (MRK) drugs under commissioner national priority voucher pilot...
PFE.US
Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
** Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance; sees FY25 revenue guidance at USD 62bln...
Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030
** Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030** Pfizer anticipates growth in...
US President Trump set to interview Fed Governor Waller for the Chair role on...
** US President Trump set to interview Fed Governor Waller for the Chair role on Wednesday, WSJ reports** Betting...
US Equities
Lockheed Martin (LMT) expects to recognise a non-cash
Lockheed Martin (LMT) expects to recognise a non-cash, non-operating pre-tax settlement charge of approximately...
Meta (META) is developing a new AI image and video model codenamed 'Mango'
Meta (META) is developing a new AI image and video model codenamed 'Mango', according to WSJ. Meta is developing a...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which co...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which could value it as much as USD 830bln,...

Nasdaq will be open as scheduled on Wednesday
Nasdaq will be open as scheduled on Wednesday, December 24th and Friday, December 26th Traders are closely...

Trump Media and Technology (DJT) says if merger is terminated under certain c...
Trump Media and Technology (DJT) says if merger is terminated under certain conditions, TAE may be obliged to pay...

Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of a 1.5% drop to USD 11.43bln Nike...
Nike (NKE) CEO says dimensions of their businesses are moving at different sp...
Nike (NKE) CEO says dimensions of their businesses are moving at different speeds and recovery will take time,...
AIG (AIG) is to form a special purpose vehicle for a strategic partnership wi...
AIG (AIG) is to form a special purpose vehicle for a strategic partnership with Amwins and Blackstone (BX US) and...
FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects ope...
FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects operating expenses to rise in Q3 due to...
The first phase of a Nanto data centre cluster would have 400-megawatt power ...
The first phase of a Nanto (?? CH) data centre cluster would have 400-megawatt power capacity, which would be...
Capital One (COF) reportedly concerned about AI costs rising via cloud comput...
Capital One (COF) reportedly concerned about AI costs rising via cloud computing relationship with AWS (AMZN) and...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...
CALENDAR UPDATE: USTR Greer will be appearing on Bloomberg TV at 13:15GMT/08:...
CALENDAR UPDATE: USTR Greer will be appearing on Bloomberg TV at 13:15GMT/08:15EST Traders are closely monitoring...

Conagra Brands Inc (CAG) Q2 2026 (USD): Adj. EPS 0.45 (exp. 0.44)
Conagra Brands Inc (CAG) Q2 2026 (USD): Adj. EPS 0.45 (exp. 0.44), Revenue 3.00bln (exp. 3.00bln) Conagra Brands...

BioMarin (BMRN) to acquire Amicus Therapeutics (FOLD) for USD 14.50/shr in al...
BioMarin (BMRN) to acquire Amicus Therapeutics (FOLD) for USD 14.50/shr in all-cash transaction; deal expected to...

Union Pacific (UNP) and Norfolk Southern (NSC) filed for merger approval with...
Union Pacific (UNP) and Norfolk Southern (NSC) filed for merger approval with STB Traders are closely monitoring...
Germany
German GfK Consumer Sentiment (Jan) -26.9 vs. Exp. -23.2 (Prev. -23.2
German GfK Consumer Sentiment (Jan) -26.9 vs. Exp. -23.2 (Prev. -23.2, Rev. -23.4) Traders are closely monitoring...
European Movers: Renault (RNO FP) +1.2%
European Movers: Renault (RNO FP) +1.2%, Ipsen (IPN FP) -1.5%, Adidas (ADS GY) -1.8%, Puma (PUM GY) -2.8%, WH...
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM)
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM), Volkswagen (VOW3 GY), Tesla (TSLA)...

Bundesbank cuts growth forecast for 2026 to 0.6% (prev. 0.7%) and raises 2026...
Bundesbank cuts growth forecast for 2026 to 0.6% (prev. 0.7%) and raises 2026 inflation forecast for Germany to...

AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...

US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Newsquawk Daily Economic Releases - 23rd December 2025
Newsquawk Daily Economic Releases - 23rd December 2025 Traders are closely monitoring the release of key economic...
Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states o...
Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states over diesel emissions probe, via NY...
German Import Prices YY* (Nov) -1.9% vs. Exp. -2.2% (Prev. -1.4%)
German Import Prices YY (Nov) -1.9% vs. Exp. -2.2% (Prev. -1.4%) * Traders are closely monitoring the energy...
Airbus (AIR FP) maintains its recently revised delivery target of approximate...
Airbus (AIR FP) maintains its recently revised delivery target of approximately 790 aircraft for 2025, according...
German ZEW Current Conditions (Dec) -81.0 vs. Exp. -80.0 (Prev. -78.7)
** German ZEW Current Conditions (Dec) -81.0 vs. Exp. -80.0 (Prev. -78.7)** Traders are closely monitoring the...
German Government Official says the Mercosur trade pact is "probably dead" if...
** German Government Official says the Mercosur trade pact is "probably dead" if an agreement isn't made at the EU...
BASF (BAS GY) is to divest its optical brightening agent business to Catexel
** BASF (BAS GY) is to divest its optical brightening agent business to Catexel (?? LN), with the transaction...

BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
** BMW (BMY GY) says planned conversion of all preferred shares into ordinary shares; further details will be...

Newsquawk Daily Economic Releases - 17th December 2025
** I'm sorry, but the text provided does not contain any company names to process. If you have more text or...

US President Trump set to interview Fed Governor Waller for the Chair role on...
** US President Trump set to interview Fed Governor Waller for the Chair role on Wednesday, WSJ reports** Betting...
MRK
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...

BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley
** BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley** Core Scientific (CORZ) receives an...

US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
** US FDA moving to fast-track reviews of two Merck (MRK) drugs under commissioner national priority voucher pilot...
PFE
Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
** Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance; sees FY25 revenue guidance at USD 62bln...
US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
** US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP** Ford's strategic shift away from electric vehicles (EVs) is...
Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030
** Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030** Pfizer anticipates growth in...

US President Trump set to interview Fed Governor Waller for the Chair role on...
** US President Trump set to interview Fed Governor Waller for the Chair role on Wednesday, WSJ reports** Betting...

Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck KGaA
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...
Equities
Lockheed Martin (LMT) expects to recognise a non-cash
Lockheed Martin (LMT) expects to recognise a non-cash, non-operating pre-tax settlement charge of approximately...
Meta (META) is developing a new AI image and video model codenamed 'Mango'
Meta (META) is developing a new AI image and video model codenamed 'Mango', according to WSJ. Meta is developing a...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which co...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which could value it as much as USD 830bln,...

Trump Media and Technology (DJT) says if merger is terminated under certain c...
Trump Media and Technology (DJT) says if merger is terminated under certain conditions, TAE may be obliged to pay...

Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of a 1.5% drop to USD 11.43bln Nike...

Nike (NKE) CEO says dimensions of their businesses are moving at different sp...
Nike (NKE) CEO says dimensions of their businesses are moving at different speeds and recovery will take time,...
FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects ope...
FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects operating expenses to rise in Q3 due to...
Downer EDI (DOW AT) selected as preferred contractor for NZTA highway contracts
Downer EDI (DOW AT) selected as preferred contractor for NZTA highway contracts, with estimated total revenue from...
PRE-MARKET TAIWAN AND SINGAPORE STOCKS NEWS: Singapore Telecommunications (ST...
PRE-MARKET TAIWAN AND SINGAPORE STOCKS NEWS: Singapore Telecommunications (ST SP) unit Optus was criticised in...
PRE-MARKET CHINESE STOCKS NEWS: TikTok has signed a deal to sell its US entit...
PRE-MARKET CHINESE STOCKS NEWS: TikTok (?? CH) has signed a deal to sell its US entity to a joint venture...
Phillips 66 (PSX) reports emissions event at Sweeney refinery and petrochemic...
Phillips 66 (PSX) reports emissions event at Sweeney refinery and petrochemical complex in Texas on December 17th...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the ...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the formation of a JV with Coal India...
US Homeland Security Secretary Noem says at President Trump's direction
US Homeland Security Secretary Noem says at President Trump's direction, she is immediately directing the USCIS to...

Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of ...
Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of Pfizer (PFE) drugs for five years...

The first phase of a Nanto data centre cluster would have 400-megawatt power ...
The first phase of a Nanto (?? CH) data centre cluster would have 400-megawatt power capacity, which would be...

Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
S&P 500 Index
Meta (META) is developing a new AI image and video model codenamed 'Mango'
Meta (META) is developing a new AI image and video model codenamed 'Mango', according to WSJ. Meta is developing a...
Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of a 1.5% drop to USD 11.43bln Nike...
Nike (NKE) CEO says dimensions of their businesses are moving at different sp...
Nike (NKE) CEO says dimensions of their businesses are moving at different speeds and recovery will take time,...

AIG (AIG) is to form a special purpose vehicle for a strategic partnership wi...
AIG (AIG) is to form a special purpose vehicle for a strategic partnership with Amwins and Blackstone (BX US) and...

FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects ope...
FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects operating expenses to rise in Q3 due to...

Downer EDI (DOW AT) selected as preferred contractor for NZTA highway contracts
Downer EDI (DOW AT) selected as preferred contractor for NZTA highway contracts, with estimated total revenue from...
China Commerce Ministry says the Vice Minister met with the General Manager o...
China Commerce Ministry says the Vice Minister met with the General Manager of NXP Semiconductors (NXPI) China...
PRE-MARKET CHINESE STOCKS NEWS: TikTok has signed a deal to sell its US entit...
PRE-MARKET CHINESE STOCKS NEWS: TikTok (?? CH) has signed a deal to sell its US entity to a joint venture...
US President Trump administration initiates multi-agency review of NVIDIA (NV...
US President Trump administration initiates multi-agency review of NVIDIA (NVDA) H200 licenses for sales to China,...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the ...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the formation of a JV with Coal India...
The first phase of a Nanto data centre cluster would have 400-megawatt power ...
The first phase of a Nanto (?? CH) data centre cluster would have 400-megawatt power capacity, which would be...
Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
US ambassador to Israel says the US is not considering supplying Turkey with ...
US ambassador to Israel says the US is not considering supplying Turkey with F-35 jets (LMT), which is not on the...

European Movers: Renault (RNO FP) +1.2%
European Movers: Renault (RNO FP) +1.2%, Ipsen (IPN FP) -1.5%, Adidas (ADS GY) -1.8%, Puma (PUM GY) -2.8%, WH...

Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM)
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM), Volkswagen (VOW3 GY), Tesla (TSLA)...

Germany's Competition Authority approves the merger of Palo Alto (PANW) and I...
Germany's Competition Authority approves the merger of Palo Alto (PANW) and Israel's Cyberark (?? CH) software...
DAX 40 Index
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM)
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM), Volkswagen (VOW3 GY), Tesla (TSLA)...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...

Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states o...
Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states over diesel emissions probe, via NY...

European Movers: ASML (ASML NA) +3.0%
European Movers: ASML (ASML NA) +3.0%, Balfour Beatty (BBY LN) +2.5%, Alstom (ALO FP) +1.8%, Airbus (AIR FP)...

Airbus (AIR FP) maintains its recently revised delivery target of approximate...
Airbus (AIR FP) maintains its recently revised delivery target of approximately 790 aircraft for 2025, according...
BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
** BMW (BMY GY) says planned conversion of all preferred shares into ordinary shares; further details will be...
US President Trump set to interview Fed Governor Waller for the Chair role on...
** US President Trump set to interview Fed Governor Waller for the Chair role on Wednesday, WSJ reports** Betting...
European Movers: HSBC (HSBA LN) +2.2%
** European Movers: HSBC (HSBA LN) +2.2%, Serco (SRP LN) +2.1%, Glencore (GLEN LN) +1.3%, Thyssenkrupp Nucera...
S&P says Airbus (AIR FP) outlook revised to positive on steady free cash flow...
** S&P says Airbus (AIR FP) outlook revised to positive on steady free cash flow generation; 'A' rating affirmed**...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...
Rheinmetall (RHM GY) secures major contract worth EUR 1.7bln for space reconn...
** Rheinmetall (RHM GY) secures major contract worth EUR 1.7bln for space reconnaissance** Traders are closely...

Rheinmetall (RHM GY) announces EUR 350mln non-cash impairment for discontinue...
** Rheinmetall (RHM GY) announces EUR 350mln non-cash impairment for discontinued operations; decided to initiate...

US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
** US FDA moving to fast-track reviews of two Merck (MRK) drugs under commissioner national priority voucher pilot...

PRE-MARKET TAIWAN AND SINGAPORE STOCKS NEWS: First Financial Holding (2892 TT...
** PRE-MARKET TAIWAN AND SINGAPORE STOCKS NEWS: First Financial Holding (2892 TT) unit buys two Airbus (AIR FP)...
Europe
Brazil Central Bank is to offer USD 2bln in dollar auctions with repurchase a...
Brazil Central Bank is to offer USD 2bln in dollar auctions with repurchase agreement on Friday Traders are...
Lockheed Martin (LMT) expects to recognise a non-cash
Lockheed Martin (LMT) expects to recognise a non-cash, non-operating pre-tax settlement charge of approximately...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which co...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which could value it as much as USD 830bln,...

Trump Media and Technology (DJT) says if merger is terminated under certain c...
Trump Media and Technology (DJT) says if merger is terminated under certain conditions, TAE may be obliged to pay...

Chinese auto parts company Wangxiang agrees to pay USD 53mln to resolve US Ju...
Chinese auto parts company Wangxiang (Wangxiang CH) agrees to pay USD 53mln to resolve US Justice Department...

Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of a 1.5% drop to USD 11.43bln Nike...
World Bank approves a USD 500mln guarantee to boost infrastructure and attrac...
World Bank approves a USD 500mln guarantee to boost infrastructure and attract private investment in Mexico...
PRE-MARKET CHINESE STOCKS NEWS: TikTok has signed a deal to sell its US entit...
PRE-MARKET CHINESE STOCKS NEWS: TikTok (?? CH) has signed a deal to sell its US entity to a joint venture...
US President Trump administration initiates multi-agency review of NVIDIA (NV...
US President Trump administration initiates multi-agency review of NVIDIA (NVDA) H200 licenses for sales to China,...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the ...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the formation of a JV with Coal India...
Adani airport unit invests USD 11bln and seeks a partner pre-IPO
Adani airport unit invests USD 11bln and seeks a partner pre-IPO, according to Bloomberg Adani's airport unit...
Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
Swedish Manufacturing Confidence* (Dec) 103.8 (Prev. 100.9)
Swedish Manufacturing Confidence (Dec) 103.8 (Prev. 100.9) * Traders are closely monitoring the energy sector amid...

UK Trade Minister Bryant confirms a hack of Government data
UK Trade Minister Bryant confirms a hack of Government data UK Trade Minister Bryant confirms a significant data...

Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%)
Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%) Traders are closely monitoring the energy sector amid fluctuating...

Belarus says "We are preparing to start the combat shift of the Russian Orysh...
Belarus says "We are preparing to start the combat shift of the Russian Oryshnik missile system", via Al Arabiya...
EU Session
"Iran's Judiciary on Protests: We Will Show No Mercy", according to Al Arabiya
"Iran's Judiciary on Protests: We Will Show No Mercy", according to Al Arabiya Iran's Judiciary has vowed no mercy...
Manchester United (MANU) sack Ruben Amorim as head coach
Manchester United (MANU) sack Ruben Amorim as head coach Manchester United (MANU) have dismissed Ruben Amorim as...
ICICI Bank (ICICIBC IS) plans to maintain majority stake in ICICI Prudential ...
ICICI Bank (ICICIBC IS) plans to maintain majority stake in ICICI Prudential Asset Management (ICICIAMC IS)...

German GfK Consumer Sentiment (Jan) -26.9 vs. Exp. -23.2 (Prev. -23.2
German GfK Consumer Sentiment (Jan) -26.9 vs. Exp. -23.2 (Prev. -23.2, Rev. -23.4) Traders are closely monitoring...

BoJ Governor Ueda (post-policy press conference) says Japan's economy is reco...
BoJ Governor Ueda (post-policy press conference) says Japan's economy is recovering moderately, albeit with some...

The first phase of a Nanto data centre cluster would have 400-megawatt power ...
The first phase of a Nanto (?? CH) data centre cluster would have 400-megawatt power capacity, which would be...
BlueScope Steel (BSL AT) reportedly received a bid from an Australian and US ...
BlueScope Steel (BSL AT) reportedly received a bid from an Australian and US consortium at AUD 30/shr BlueScope...
UK PSNB Ex Banks GBP (Nov) 11.653B GB vs. Exp. 10.0B GB (Prev. 17.434B GB
UK PSNB Ex Banks GBP (Nov) 11.653B GB vs. Exp. 10.0B GB (Prev. 17.434B GB, Rev. 21.189B GB) Traders are closely...
Swedish Manufacturing Confidence* (Dec) 103.8 (Prev. 100.9)
Swedish Manufacturing Confidence (Dec) 103.8 (Prev. 100.9) * Traders are closely monitoring the energy sector amid...
Turkish Consumer Confidence* (Dec) 83.5 (Prev. 85.0)
Turkish Consumer Confidence (Dec) 83.5 (Prev. 85.0) * Traders are closely monitoring the energy sector amid...
UK Trade Minister Bryant confirms a hack of Government data
UK Trade Minister Bryant confirms a hack of Government data UK Trade Minister Bryant confirms a significant data...
China's Foreign Ministry on Japanese official talking about nuclear arms
China's Foreign Ministry on Japanese official talking about nuclear arms, says if the reports are true, then the...
Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%)
Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%) Traders are closely monitoring the energy sector amid fluctuating...

Belarus says "We are preparing to start the combat shift of the Russian Orysh...
Belarus says "We are preparing to start the combat shift of the Russian Oryshnik missile system", via Al Arabiya...

French Producer Prices MM (Nov) 1.1%
French Producer Prices MM (Nov) 1.1% Traders are closely monitoring the energy sector amid fluctuating oil prices....

China's Commerce Ministry has launched an investigation into some rubber prod...
China's Commerce Ministry has launched an investigation into some rubber products from the US, South Korea and the...
















