Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival

** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and pathological complete response rates for Cisplatin-eligible patients with MIBC when given before and after surgery.**
- Traders are closely monitoring the energy sector amid fluctuating oil prices.
- Analysts note increased attention on USD/JPY as currency volatility rises.
- Market participants are assessing the impact of recent inflation data on bond yields.
In recent trading sessions, market participants have been closely observing the energy sector, particularly in light of fluctuating oil prices. The volatility in WTI crude oil has prompted traders to reassess their positions in energy-related assets. The Energy Select Sector SPDR Fund (XLE) has been a focal point for those looking to gain exposure to potential shifts in the sector. Analysts note that the energy market's dynamics are being influenced by a combination of supply chain disruptions and geopolitical tensions, which could lead to further price swings.
Currency markets are also under scrutiny, with the USD/JPY pair drawing significant attention. The pair's movements have been influenced by recent inflation data, which has sparked discussions among traders about potential shifts in monetary policy. The Japanese yen's performance against the US dollar is being closely watched as traders assess the implications of inflationary pressures on central bank actions. Some market participants are considering the potential for increased volatility in the currency pair as economic indicators continue to evolve.
In the bond market, recent inflation data has led to heightened interest in government bonds, particularly the US 10-Year Treasury. Traders are evaluating the impact of inflation on bond yields, with some considering the potential for rising yields to affect broader market sentiment. The interplay between inflation expectations and bond yields remains a critical area of focus, as it could influence investment strategies across various asset classes.
Overall, the current market environment is characterised by a heightened sense of uncertainty, with traders and analysts alike keeping a close eye on key economic indicators and geopolitical developments. The interplay between these factors is likely to continue shaping market sentiment in the coming weeks.
Trader Insight:
- Some traders may consider positioning in USD/JPY following the inflation data, as currency volatility remains a key focus.
- Market participants are watching XLE for signs of renewed energy rotation amid fluctuating oil prices.
- Analysts note that traders are assessing the impact of recent inflation data on US 10-Year Treasury yields, with potential implications for broader market sentiment.
Disclaimer: This is not trading advice. For informational purposes only.
Merck (MRK) initiates Phase 3 KANDLELIT-007 Trial Evaluating Calderasib (MK-1...
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EU HCOB Construction PMI (Dec) 47.4 vs. Exp. 46.9 (Prev. 45.4)
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US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
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European Movers: Telecom Italia (TIT IM) +1.4%
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European Movers: Sika (SIKA SW) +0.6%
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US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
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European Movers: Telecom Italia (TIT IM) +1.4%
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European Movers: Sika (SIKA SW) +0.6%
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Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
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US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
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Pfizer (PFE) CEO says the Co. is well positioned for growth in 2029 and 2030
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BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
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US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
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GSK (GSK LN)
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ECB's Kazimir says that the ECB remains flexible and will be ready to step in...
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European Movers: Sika (SIKA SW) +0.6%
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Pfizer (PFE) reaffirms FY25 EPS guidance and provides FY26 guidance
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US PRE-MARKET MOVERS: F, PFE, WM, PYPL, MCHP, ADP
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Merck & Co Inc
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
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MRK.US
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Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
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US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
** US FDA moving to fast-track reviews of two Merck (MRK) drugs under commissioner national priority voucher pilot...
Equities
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Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
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FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects ope...
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US Homeland Security Secretary Noem says at President Trump's direction
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Cipla (CIPLA IS) wins exclusive supply and marketing deal for four brands of ...
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Additional European Equity News
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US Equities
Lockheed Martin (LMT) expects to recognise a non-cash
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Meta (META) is developing a new AI image and video model codenamed 'Mango'
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OpenAI is aiming to raise as much as USD 100bln in fundraising round which co...
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Trump Media and Technology (DJT) says if merger is terminated under certain c...
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Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
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AbbVie (ABBV)
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Union Pacific (UNP) and Norfolk Southern (NSC) filed for merger approval with...
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Germany
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European Movers: Renault (RNO FP) +1.2%
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Bundesbank cuts growth forecast for 2026 to 0.6% (prev. 0.7%) and raises 2026...
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AbbVie (ABBV)
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US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
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Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states o...
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Airbus (AIR FP) maintains its recently revised delivery target of approximate...
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German Government Official says the Mercosur trade pact is "probably dead" if...
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BASF (BAS GY) is to divest its optical brightening agent business to Catexel
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BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
** BMW (BMY GY) says planned conversion of all preferred shares into ordinary shares; further details will be...

Newsquawk Daily Economic Releases - 17th December 2025
** I'm sorry, but the text provided does not contain any company names to process. If you have more text or...

US President Trump set to interview Fed Governor Waller for the Chair role on...
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MRK
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...

BROKER MOVES: CORZ upgraded at Citizens; PYPL downgraded at Morgan Stanley
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US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
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Merck KGaA
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...
S&P 500 Index
Meta (META) is developing a new AI image and video model codenamed 'Mango'
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Nike (NKE) CEO says dimensions of their businesses are moving at different sp...
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AIG (AIG) is to form a special purpose vehicle for a strategic partnership wi...
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FedEx (FDX) CFO says expects Q3 revenue to be in line with Q2 and expects ope...
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Downer EDI (DOW AT) selected as preferred contractor for NZTA highway contracts
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US ambassador to Israel says the US is not considering supplying Turkey with ...
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European Movers: Renault (RNO FP) +1.2%
European Movers: Renault (RNO FP) +1.2%, Ipsen (IPN FP) -1.5%, Adidas (ADS GY) -1.8%, Puma (PUM GY) -2.8%, WH...

Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM)
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM), Volkswagen (VOW3 GY), Tesla (TSLA)...

Germany's Competition Authority approves the merger of Palo Alto (PANW) and I...
Germany's Competition Authority approves the merger of Palo Alto (PANW) and Israel's Cyberark (?? CH) software...
DAX 40 Index
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM)
Italy's Competition Authority ends probes of Stellantis (STLAP FP/ STLAM IM), Volkswagen (VOW3 GY), Tesla (TSLA)...
AbbVie (ABBV)
AbbVie (ABBV), Merck (MRK), Bristol-Myers Squibb (BMY) and Gilead (GILD) to announce US drug price deals on...
US U Mich Sentiment Final* (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3)
US U Mich Sentiment Final (Dec) 52.9 vs. Exp. 53.4 (Prev. 53.3) * Traders are closely monitoring the energy sector...

Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states o...
Mercedes-Benz (MBG GY) agrees to pay USD 150mln settlement with U.S. states over diesel emissions probe, via NY...

European Movers: ASML (ASML NA) +3.0%
European Movers: ASML (ASML NA) +3.0%, Balfour Beatty (BBY LN) +2.5%, Alstom (ALO FP) +1.8%, Airbus (AIR FP)...

Airbus (AIR FP) maintains its recently revised delivery target of approximate...
Airbus (AIR FP) maintains its recently revised delivery target of approximately 790 aircraft for 2025, according...
BMW (BMY GY) says planned conversion of all preferred shares into ordinary sh...
** BMW (BMY GY) says planned conversion of all preferred shares into ordinary shares; further details will be...
US President Trump set to interview Fed Governor Waller for the Chair role on...
** US President Trump set to interview Fed Governor Waller for the Chair role on Wednesday, WSJ reports** Betting...
European Movers: HSBC (HSBA LN) +2.2%
** European Movers: HSBC (HSBA LN) +2.2%, Serco (SRP LN) +2.1%, Glencore (GLEN LN) +1.3%, Thyssenkrupp Nucera...
S&P says Airbus (AIR FP) outlook revised to positive on steady free cash flow...
** S&P says Airbus (AIR FP) outlook revised to positive on steady free cash flow generation; 'A' rating affirmed**...
Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen withou...
** Pfizer's (PFE) PADCEV plus Merck's (MRK) Keytruda is the first regimen without platinum-based chemotherapy to...
Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival
** Merck (MRK) says Keytruda plus Padcev significantly improved event-free survival, overall survival, and...
Rheinmetall (RHM GY) secures major contract worth EUR 1.7bln for space reconn...
** Rheinmetall (RHM GY) secures major contract worth EUR 1.7bln for space reconnaissance** Traders are closely...

Rheinmetall (RHM GY) announces EUR 350mln non-cash impairment for discontinue...
** Rheinmetall (RHM GY) announces EUR 350mln non-cash impairment for discontinued operations; decided to initiate...

US FDA moving to fast-track reviews of two Merck (MRK) drugs under commission...
** US FDA moving to fast-track reviews of two Merck (MRK) drugs under commissioner national priority voucher pilot...

PRE-MARKET TAIWAN AND SINGAPORE STOCKS NEWS: First Financial Holding (2892 TT...
** PRE-MARKET TAIWAN AND SINGAPORE STOCKS NEWS: First Financial Holding (2892 TT) unit buys two Airbus (AIR FP)...
Europe
Brazil Central Bank is to offer USD 2bln in dollar auctions with repurchase a...
Brazil Central Bank is to offer USD 2bln in dollar auctions with repurchase agreement on Friday Traders are...
Lockheed Martin (LMT) expects to recognise a non-cash
Lockheed Martin (LMT) expects to recognise a non-cash, non-operating pre-tax settlement charge of approximately...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which co...
OpenAI is aiming to raise as much as USD 100bln in fundraising round which could value it as much as USD 830bln,...

Trump Media and Technology (DJT) says if merger is terminated under certain c...
Trump Media and Technology (DJT) says if merger is terminated under certain conditions, TAE may be obliged to pay...

Chinese auto parts company Wangxiang agrees to pay USD 53mln to resolve US Ju...
Chinese auto parts company Wangxiang (Wangxiang CH) agrees to pay USD 53mln to resolve US Justice Department...

Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of...
Nike (NKE) expects Q3 revenue to decline by low single-digits vs estimates of a 1.5% drop to USD 11.43bln Nike...
World Bank approves a USD 500mln guarantee to boost infrastructure and attrac...
World Bank approves a USD 500mln guarantee to boost infrastructure and attract private investment in Mexico...
PRE-MARKET CHINESE STOCKS NEWS: TikTok has signed a deal to sell its US entit...
PRE-MARKET CHINESE STOCKS NEWS: TikTok (?? CH) has signed a deal to sell its US entity to a joint venture...
US President Trump administration initiates multi-agency review of NVIDIA (NV...
US President Trump administration initiates multi-agency review of NVIDIA (NVDA) H200 licenses for sales to China,...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the ...
PRE-MARKET INDIAN STOCKS NEWS: Bharat Petroleum (BPCL IS) board approved the formation of a JV with Coal India...
Adani airport unit invests USD 11bln and seeks a partner pre-IPO
Adani airport unit invests USD 11bln and seeks a partner pre-IPO, according to Bloomberg Adani's airport unit...
Additional European Equity News
Additional European Equity News Balfour Beatty generates GBP 24mln profit from the sale of Foundry Courtyard. BBVA...
Swedish Manufacturing Confidence* (Dec) 103.8 (Prev. 100.9)
Swedish Manufacturing Confidence (Dec) 103.8 (Prev. 100.9) * Traders are closely monitoring the energy sector amid...

UK Trade Minister Bryant confirms a hack of Government data
UK Trade Minister Bryant confirms a hack of Government data UK Trade Minister Bryant confirms a significant data...

Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%)
Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%) Traders are closely monitoring the energy sector amid fluctuating...

Belarus says "We are preparing to start the combat shift of the Russian Orysh...
Belarus says "We are preparing to start the combat shift of the Russian Oryshnik missile system", via Al Arabiya...
EU Session
"Iran's Judiciary on Protests: We Will Show No Mercy", according to Al Arabiya
"Iran's Judiciary on Protests: We Will Show No Mercy", according to Al Arabiya Iran's Judiciary has vowed no mercy...
Manchester United (MANU) sack Ruben Amorim as head coach
Manchester United (MANU) sack Ruben Amorim as head coach Manchester United (MANU) have dismissed Ruben Amorim as...
ICICI Bank (ICICIBC IS) plans to maintain majority stake in ICICI Prudential ...
ICICI Bank (ICICIBC IS) plans to maintain majority stake in ICICI Prudential Asset Management (ICICIAMC IS)...

German GfK Consumer Sentiment (Jan) -26.9 vs. Exp. -23.2 (Prev. -23.2
German GfK Consumer Sentiment (Jan) -26.9 vs. Exp. -23.2 (Prev. -23.2, Rev. -23.4) Traders are closely monitoring...

BoJ Governor Ueda (post-policy press conference) says Japan's economy is reco...
BoJ Governor Ueda (post-policy press conference) says Japan's economy is recovering moderately, albeit with some...

The first phase of a Nanto data centre cluster would have 400-megawatt power ...
The first phase of a Nanto (?? CH) data centre cluster would have 400-megawatt power capacity, which would be...
BlueScope Steel (BSL AT) reportedly received a bid from an Australian and US ...
BlueScope Steel (BSL AT) reportedly received a bid from an Australian and US consortium at AUD 30/shr BlueScope...
UK PSNB Ex Banks GBP (Nov) 11.653B GB vs. Exp. 10.0B GB (Prev. 17.434B GB
UK PSNB Ex Banks GBP (Nov) 11.653B GB vs. Exp. 10.0B GB (Prev. 17.434B GB, Rev. 21.189B GB) Traders are closely...
Swedish Manufacturing Confidence* (Dec) 103.8 (Prev. 100.9)
Swedish Manufacturing Confidence (Dec) 103.8 (Prev. 100.9) * Traders are closely monitoring the energy sector amid...
Turkish Consumer Confidence* (Dec) 83.5 (Prev. 85.0)
Turkish Consumer Confidence (Dec) 83.5 (Prev. 85.0) * Traders are closely monitoring the energy sector amid...
UK Trade Minister Bryant confirms a hack of Government data
UK Trade Minister Bryant confirms a hack of Government data UK Trade Minister Bryant confirms a significant data...
China's Foreign Ministry on Japanese official talking about nuclear arms
China's Foreign Ministry on Japanese official talking about nuclear arms, says if the reports are true, then the...
Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%)
Hungarian Gross Wages YY (Oct) 8.7% (Prev. 9.5%) Traders are closely monitoring the energy sector amid fluctuating...

Belarus says "We are preparing to start the combat shift of the Russian Orysh...
Belarus says "We are preparing to start the combat shift of the Russian Oryshnik missile system", via Al Arabiya...

French Producer Prices MM (Nov) 1.1%
French Producer Prices MM (Nov) 1.1% Traders are closely monitoring the energy sector amid fluctuating oil prices....

China's Commerce Ministry has launched an investigation into some rubber prod...
China's Commerce Ministry has launched an investigation into some rubber products from the US, South Korea and the...
















